Avinza (Morphine Sulfate) 90 mg
Uses. This medication is used to help relieve severe ongoing pain (such as due to cancer). Morphine belongs to a class of drugs known as opioid (narcotic) analgesics. It works in the brain to change how your body feels and responds to pain. The higher strengths of this drug (90 and 120 milligrams per capsule) should be …
morphine sulfate extended-release capsules) 30, 60, 90, and 120 mg contain both immediate release and extended release beads of morphine sulfate for once daily oral administration. uses the proprietary SODAS® (Spheroidal Oral Drug Absorption System) technology to produce the extended release component of AVINZA, which combined with an immediate release component achieves the desired release profile characteristics of AVINZA capsules. Within the gastrointestinal tract, due to the permeability of the ammonio‑methacrylate copolymers of the beads, fluid enters the beads and solubilizes the drug. This is mediated by fumaric acid, which acts as an osmotic agent and a local pH modifier. The resultant solution then diffuses out in a predetermined manner which prolongs the in vivo dissolution and absorption phases. Avinza (Morphine Sulfate) 90 mg
INDICATIONS & USAGE
AVINZA: capsules are a modified-release formulation of morphine sulfate intended for once daily administration indicated for the relief of moderate to severe pain requiring continuous, around-the-clock opioid therapy for an extended period of time.
AVINZA: is NOT intended for use as a prn analgesic.
The safety and efficacy of using AVINZA in the postoperative setting has not been evaluated. AVINZA: is not indicated for postoperative use. If the patient has been receiving the drug prior to surgery, resumption of the pre-surgical dose may be appropriate once the patient is able to take the drug by mouth. Physicians should individualize treatment, moving from parenteral to oral analgesics as appropriate. (see American Pain Society guidelines. Avinza (Morphine Sulfate) 90 mg
AVINZA is intended for use in patients requiring continuous around-the-clock treatment with an opioid analgesic. It is not appropriate as a prn treatment for pain. As with any opioid, it is critical to adjust the dose of AVINZA for each individual patient, taking into account the patient’s prior experience with analgesics. (see DOSAGE AND ADMINISTRATION)
Use in Pancreatic/Biliary Tract Disease
AVINZA should be used with caution in patients with biliary tract disease, including acute pancreatitis, as morphine may cause spasm of the sphincter of Oddi and diminish biliary and pancreatic secretions. Avinza (Morphine Sulfate) 90 mg
Special Risk Groups
AVINZA should be administered cautiously and in reduced dosages in patients with severe renal or hepatic insufficiency, Addison’s disease, hypothyroidism, prostatic hypertrophy, or urethral stricture, and in elderly or debilitated patients. (see GERIATRIC USE and CLINICAL PHARMACOLOGY, SPECIAL POPULATIONS)
Caution should be exercised in the administration of morphine to patients with CNS depression, toxic psychosis, acute alcoholism and delirium tremens, and seizure disorders.
Driving and Operating Machinery
Patients should be cautioned that AVINZA could impair the mental and/or physical abilities needed to perform potentially hazardous activities such as driving a car or operating machinery.
Patients should also be cautioned about the potential combined effects of AVINZA with other CNS depressants, including other opioids, phenothiazines, sedative/hypnotics and alcohol. (see PRECAUTIONS, DRUG INTERACTIONS)
Tolerance and Physical Dependence
Tolerance is the need for increasing doses of opioids to maintain a defined effect such as analgesia (in the absence of disease progression or other external factors). Physical dependence is manifested by withdrawal symptoms after abrupt discontinuation of a drug or upon administration of an antagonist. Physical dependence and tolerance are not unusual during chronic opioid therapy. Avinza (Morphine Sulfate) 90 mg
The opioid abstinence or withdrawal syndrome is characterized by some or all of the following: restlessness, lacrimation, rhinorrhea, yawning, perspiration, chills, myalgia, and mydriasis. Other symptoms also may develop, including irritability, anxiety, backache, joint pain, weakness, abdominal cramps, insomnia, nausea, anorexia, vomiting, diarrhea, or increased blood pressure, respiratory rate, or heart rate. Avinza (Morphine Sulfate) 90 mg